Bisphosphonate-related osteonecrosis of the jaw in patients received long term treatment of oral bisphosphonate administration: Case reports
최해인, 김수관, 오지수, 유재식, 김원기, Yu Kyung-Hwan, 임형섭, 김재성,
소속 상세정보
최해인 ( Choi Hae-In ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
김수관 ( Kim Su-Gwan ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
오지수 ( Oh Ji-Su ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
유재식 ( You Jae-Seek ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
김원기 ( Kim Won-Gi ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
( Yu Kyung-Hwan ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
임형섭 ( Lim Hyung-Seop ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
김재성 ( Kim Jae-Sung ) - Chosun University College of Health Science Department of Natural Medical Sciences
KMID : 0353420160400010043
Abstract
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing every year, as the number of elders receiving bisphosphonate (BPs) therapy is increases. It is believed that BPs enhance the ORN by inhibition of the osteoclastic activity, but the exact mechanism is poorly understood. Patients who had received long-term oral BP therapy had a high recurrence rate of BRONJ. They needed to undergo segmental mandibulectomy and reconstruction, beyond getting just the conservative treatment, such as sequestrectomy. We present 2 such cases in this report. The patients had 7 years and 13 years of oral BP administration, respectively. These cases are being reported as we had good results after reconstruction, using reconstruction plate subsequent to segmental mandibulectomy.
키워드
Bisphosphonate-associated osteonecrosis of the jaw; Jaw disease; Spontaneous fracture
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